Vaiomer - Bacterial Translocation Services
Bacterial translocation: the missing link between intestinal microbiome and human complex non-communicable diseases. Complex disorders are multifactorial and often chronic, caused by genetic and environmental factors and comprising hundreds of conditions from cardio-metabolic diseases to neurodegenerative and mental disorders. These pathologies commonly present a low- to high-grade inflammation and have been associated with gut microbiota dysbiosis or a distinct microbial signature. However, how the intestinal microbiome can remotely affect all the parts of the body remains elusive. The translocation of living bacteria and/or bacterial components (e.g. nucleic acids or lipopolysaccharides) from the intestines to the bloodstream and towards other tissues may be the missing link between gut microbiota, systemic inflammation and pathogenesis.
Indeed, bacterial translocation has been shown to ...
Indeed, bacterial translocation has been shown to play a central role in the onset and/or decompensation of several pathologies, especially in cardio-metabolic disorders and liver diseases. Under pathological conditions, impairment of the intestinal barrier can lead to an increased and/or abnormal bacterial translocation that triggers a cascade of events involving local and systemic inflammation leading to tissue damage and profound metabolic changes.
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