Immune Response Services

We have been collaborating with leading clinicians, scientists and commercial partners around the globe to develop and validate a proprietary set of rapid blood tests with the aim of empowering physicians to tackle some of the most challenging clinical dilemmas. These tests build on an exquisitely informative system – the human immune system. Using low and high-throughput ...

The rapid emergence of infectious diseases, such as COVID-19, highlights the critical need to better understand the biology of viral infection, host interactions, and the immune response. ...

Their heavy-chain antibodies lack the light chain and therefore can be used to develop recombinant single-domain antibodies (VHH fragments) with several benefits: Small size: With a molecular weight of approximately 15 kDa, Easier production, High stability: As there is only one protein chain, correct refolding after physical stress keeps the functionality.We can immunize your ...

Immature DCs are professional in uptaking and processing antigens, and mature DCs are specialist in antigen presentation. It has been observed that immature cDCs can induce immune tolerance, while mature cDCs induce Th2 or Th1 immune responses. ...

A silent pandemic… Allergy is a chronic progressive disease with serious complications evolving over decades of life. Allergy can be viewed as the result of one’s immune response “stalled” in a pre-natal state, with the “normal”, protective type of immune response failing to kick-in. Genetic, ...

Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation. Methods to examine cell migration are very useful and important for a wide range of biomedical research such as cancer biology, immunology, vascular biology, cell biology and developmental biology. ...

This panel is designed to deliver immuno-oncology insights for translational research and assesses the expression of 770 genes involved in the immune response to cancer in the tumor microenvironment. We offer additional Nanostring panels and custom panels designed to fit your specific ...

Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation. Methods to examine cell migration are very useful and important for a wide range of biomedical research such as cancer biology, immunology, vascular biology, cell biology and developmental biology. ...

Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells. Through the ...

Our colorectal cancer program utilizes engineered phage with various payloads (such as immunostimulatory payloads) that are administered intravenously to target Fusobacterium nucleatum bacteria residing within the tumor microenvironment. The aim of payload delivery is to convert cold tumors to hot tumors with activated immune responses. ...

There has been an unprecedented response to the COVID-19 pandemic from the life sciences industry and research institutions to understand and respond to the effects of COVID-19, but despite first generation vaccines now being deployed to fight the disease, the need to expand our understanding of the immune response to SARS-CoV-2 still exists. ...

The tumor environment contains all the ingredients needed to mount an anticancer immune response—tumor antigens, antigen presenting cells (APCs, including tumor-associated macrophages [TAMs] and dendritic cells), and T cells—but activation of the immune system to generate that antitumor response is complex and ...

This customisable, high-throughput assay is well suited to compound screening for small molecules targeting lung fibrosis. Normal repair processes are defective in the fibrotic lung. Repetitive cellular microinjuries and a heightened immune response leads to chronic activation of fibroblasts. Activated fibroblasts differentiate into myofibroblasts, a process ...

Monoclonal antibody drugs dramatically transform modern medicine by offering targeted treatments for a variety of diseases. These antibodies specifically activate immune pathways to combat cancer, suppress autoimmunity and excessive immune responses in transplantation to relieve ...

Peptides represent a unique class of drugs with certain characteristics of small molecule drugs as well as properties of large proteins and other biologics. Most intrinsic signaling molecules are peptide-based, such as enzymes, hormones, and immune response mediators. Over 7,000 natural peptides have been identified. ...

TILs are part of the body’s natural response to cancer:The cells of the immune system perform immunosurveillance while circulating throughout the bodyAs part of the normal immune response, TIL migrate to the tumor site through recognition of chemokines produced by the tumor. ...

Working alongside our biopharmaceutical partners, we employ personalized and integrated approaches to uncover new solutions to diagnostic challenges with industry-leading expertise in blood-based ...

Our infectious disease work, in partnership with the Bill & Melinda Gates Foundation has built strong capabilities where we are developing product candidates that target pathogens that are predominant in the developing world. ...

Our list of services includes antigen consultation, peptide or protein antigen production, antibody generation, antibody purification, and conjugation to reporter molecules such as peroxidase or fluorochromes. We are experts in generating antibodies specific for post-translational modifications—including phospho-epitopes, acetylation, methylation, hydroxylation, ubiquitinylation, and ...

Antibiotic resistance is an escalating global crisis, where the spread of drug resistance is outpacing the development of new ...