Drug Target Services

Therefore, the identification of the target protein of small molecule drug action is crucial for understanding the mechanism of action and application of small molecule drugs, and can also further discover the ...

Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009, which makes it possible to track and identify target proteins whose stability changes after binding with small molecules. ...

Target validation is an essential and critical phase of the drug discovery process. This is a crucial step before starting to develop a treatment based on a targeted protein that has been identified to play a role in the disease. The target protein’s role must be clearly identified before starting to develop a ...

Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand ...

"Knocking out" related mammalian genes is an important method for studying gene function or its potential as a drug target, widely used in research on neurodegenerative diseases such as Alzheimer's disease, cancer, cardiovascular diseases, inflammation, or metabolic diseases. CRISPR/Cas9 is a revolutionary gene-editing technology that can precisely modify the ...

Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug discovery ...

Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug discovery ...

In addition, AAT Bioquest has used its Readilink™ technology to offer a rapid access to a variety of antibody conjugation products with small tag molecules such as fluorescent dyes, biotin, drug targets and haptens for our customers' special ...

InterX operates at the nexus of academic research and pharma-tech industry. We partner with leading edge researchers, drug developers, and biotechnology companies across the globe to predict drug-target interactions using the most advanced computer algorithms ...

Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. ...

Rapidly screen promising immuno-oncology targets; Sengenics helps accelerate oncology drug discovery with fast and efficient screening of immunotherapy drug ...

HTI employs cryo-EM services expertise collaborating with Pharma/Biotech science expertise to enable high-resolution structure determination of drug discovery targets. Here are a few of our leading customer ...

Nanoparticles (NPs) undergo interactions with serum proteins during systemic administration, which may result in the formation of protein corona (PC). Investigating the interplay between the chemical and biological properties of NPs enhances clinical translation efficiency. NPs with PC can be considered to exhibit a distinct biological ...

Any malfunction of key enzymes (mutation, overproduction, underproduction or deletion) can lead to diseases. Therefore, enzymes have long been considered as important drug targets for the treatment of major human ...

Targeted drug delivery Research is ongoing for the development of new drug delivery systems for targeted drug delivery. Peptides derived from sequence of cell surface proteins have shown potent binding affinity to the target cell surface ...

Binding multiple epitopes with a single antibody offers several benefits. For example, one specificity may target individual molecules while another could recruit effector cells or deliver a drug to the target. Other options include dual-target bispecifics which might detect a desired cell type with much higher selectivity than a ...

Biomolecular interaction analysis is used increasingly in drug development to kinetically characterize binding events of relevant components, including drugs and targets, antibodies and antigens or any pair of interacting molecules. Based on the Biacore 8K and ForteBio Octet platforms, ACROBiosystems provides biopharmaceutical R&D customers ...

Composed of an assortment of twenty-one libraries including FDA-approved drug library, natural product library, and anti-cancer compound library, among others, the bioactive screening libraries at BOC Sciences are ready-to-use chemical libraries for drug discovery, lab drug screening, drug target identification, ...

Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear receptors (NRs) that belong to the ...

Burning Rock offers integrated companion diagnostic development services for biopharma partners to streamline the co-development and commercialization of targeted drugs and respective CDx （including registration testing, clinical evaluation and finally obtain registration certificates. Our US-based lab and R&D team provide additional ...