Drug Resistance Services

Healthcare-associated infections (HAIs) are a widespread challenge for patient care, annually affecting 4% of hospitalized patients in the U.S. and resulting in 99,000 patient deaths per year. The rising prevalence of multi-drug resistant organisms (MDROs) has made HAIs particularly dangerous, increasing the pressure for rapid, effective interventions when an ...

Understanding the biological response can identify genes and pathways that can play a role in the efficacy of your treatment and mechanisms of drug ...

Antibiotic resistance is an escalating global crisis, where the spread of drug resistance is outpacing the development of new ...

Antimicrobial Resistance (AMR) is among the greatest global health challenges of our time. AMR occurs when a micro-organism becomes resistant to an antimicrobial medicine, such as an antibiotic. Today, an estimated 700,000 people die each year from drug-resistant infections. ...

One-third of those cases, however, are preventable if proper infection control procedures are in place. Furthermore, there is an increasing rate of infection by “superbugs”, drug-resistant strains of ...

Compared with normal cells, tumor cells have undergone a series of genetic and epigenetic alterations that, in general, underlie cancer development, progression, and drug resistance. Tumor-derived cell lines have served as important models to advance our understanding of oncogene function and therapeutic responses. Creative Bioarray provides human tumor cells ...

Minimizing the Time to Effective Antibiotic Administration is Critical; Antibiotics are critical tools for fighting life-threatening bacterial infections, but the speed with which the patient is provided the appropriate antibiotic can be the difference between life and death. For example, the risk of death from septic shock increases by almost 8% for each hour an infection goes without ...

Work on earlier programmes investigating infections in areas such as respiratory, dermal, ocular and biofilms carries on as research projects, including academic and/or commercial collaborations and grant funded ...

The outcome of your research is directly linked to the quality of the used biospecimen. In order to reflect the molecular reality, the biospecimen quality benefits from our standardized sampling by Indivumed study nurses and Indivumed trained personnel. This includes fresh-frozen tissue, FFPE samples, plasma, serum, and urine, as well as prospective collection of fresh tissue. ...

The comprehensive analysis considers commonly used treatments, as well as targeted therapy, immunotherapy, hormone therapy, and newly approved oncology drugs. These options are presented either alone (monotherapy) or in combinations of up to 4 ...

PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...

Bioactive peptides have the advantages of simple structure, high biological activity, high specificity and low toxicity, and have broad prospects in the design and development of new peptide ...

Humans are highly organized systems comprised of approximately 3.72×1013 cells of various types, which maintain proper organ function and normal cellular homeostasis. Despite significant and revolutionary discoveries in the field of cell biology, the heterogeneity of cells still requires further investigation. Single-cell RNA sequencing (scRNA-seq) has become the latest method for revealing the ...