NPOT Technology

NPOT allows us to understand the biological mechanism of a disease, a drug candidate’s mechanism of action and the origin of its side effects. This technology also enables us to identify relevant biomarkers related to a disease or associated with a drug candidate. It works by locating the target and isolating it, directly from the human tissue sample. This target is then identified and its related signaling pathway observed for pharmacological efficacy. Drug developers can then identify and validate their compound primary target and mode of action. This brings them closer to securing their drug development, funding and approval by regulatory authorities.

Conventional target deconvolution methods are unable to take into account a drug’s physiological environment, resulting in a biased ternary structure and the loss of the quaternary structure of the therapeutic target. This lost information is crucial for elucidating the biological mechanism of a disease, rational drug design, efficient structure-activity relationship studies and the investigation of aspects pertaining to target-specific toxicity and side effects. With NPOT, these key parameters are included, making your study more robust.