DiscGenics - Allogeneic Cell Culture Technology
DiscGenics uses its patented allogeneic cell culture manufacturing technology to isolate cells from donated adult human intervertebral disc tissue and induce a progenitor state. These proprietary Discogenic Cells are then expanded for therapeutic application, combined with a delivery vehicle and cryopreserved for off-the-shelf use.
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Discogenic Cells are reproducibly manufactured in a cGMP environment and are subjected to extensive testing, including identity, purity, potency and safety evaluations prior to use.
To date, comparability has been demonstrated on over a dozen cell lines, with current production capabilities allowing for the manufacture of thousands of doses from a single donor.
Discogenic Cells offer a novel approach to treating diseases of the disc. These specialized cells are hypothesized to not only possess the key regenerative and anti-inflammatory properties found in mesenchymal stem cells (MSCs), but also to produce important molecules that provide support and structure to the disc.
Importantly, prior to the culture process, Discogenic Cells begin as disc cells and already know how to behave in the unique and harsh environment of a degenerated disc. Other approaches that use unspecialized cells from sources like bone marrow or adipose fat tissue must first adapt to the disc environment before even attempting to affect it.
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