Pre-Clinical Services In USA

We are an innovative medicines company with research and development at our core. Our R&D engine powers an industry-leading pipeline focused on delivering transformative medicines to fight disease, restore possibility and help people live life on their own terms. Researchers in Biomedical Research work across several diseases areas to uncover insights into the origins and pathogenesis of ...

Phase I/IIa Combination Study of Bria-IMT™ with retifanlimab (INCMGA00012) and epacadostat in Advanced Breast Cancer. FDA has approved the combination study of Bria-IMT™ with Incyte Corporation’s drugs, retifanlimab and epacadostat. The combination study is listed in ClinicalTrials.gov as NCT03328026. Patients With advanced breast cancer will be eligible for combination therapy ...

Advancements in cancer treatments are progressing with great speed. Clinical trials offer clinical researchers and care providers more options for their patients, but finding the right trials for their patient population and matching the right patients to trials is complex and time consuming. With AI-enhanced technology and expert support services, Inteliquet offers a comprehensive solution to ...

Autophagy is a catabolic mechanism which sequesters cytoplasmic components for lysosomal-mediated degradation, including protein inclusions and damaged organelles. Autophagy has an important role in diverse physiological processes such as adaptation to nutrient starvation, cell death, embryonic development, energy metabolism, and antigen presentation, among other events. Moreover, autophagy has ...

The healthcare industry has seen an explosion of data the last five years. That’s why the utilization of a wide range of data types is now critical to the success of the drug development life cycle. With a broad range of disparate data sources to consider, how do you effectively consolidate these sources to save time, manual effort, and drive the actionable insights to support ...

Our engineers help clients achieve their goals through the identification, development, application, and transfer of leading-edge technologies. We have proven capabilities to successfully execute early- and late-stage R&D programs, and to lead programs from initial R&D to prototyping to commercialization. We have a pipeline of new technologies and actively seek to partner with industry to ...

RMS produces human induced pluripotent stem cell derived Islet-Like Clusters (ILC) for dual research tool and therapeutic use targeting diabetes. ILC were developed after over 15 years of research at the University of Wisconsin-Madison in the lab of world renowned researcher, Dr. Jon Odorico, MD, FACS and have undergone eight additional years of further research at RMS. This has resulted in ...

Sage stepped up to fill an innovation void by thinking differently about brain health disorders and how we approach the discovery and development of new ...

In alignment with our commitment to scientific innovation and areas of unmet medical need, we may provide product and funding support for independent research in rare diseases and genetic ...

Small molecule inhibitors are a class of small molecules that interact with proteins and reduce the biological activity of target proteins. The structure of small molecule inhibitors has good spatial dispersion, and their chemical properties determine their good pharmacodinemic properties and pharmacokinetic properties. These characteristics make small molecule inhibitors show great advantages in ...

Oxford Biomedical Research, Inc. has been manufacturing sandwich and competitive EIA assays for nearly 30 years. We can take your existing assay and optimize it for manufacturing and stability. Our production line is scalable from pilot lots to large-scale production. While we are capable of large production batches we’ve retained our ability to quickly modify protocols and production ...

Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. It has been widely used in current biology, functional genome ...

Structure-activity relationship (SAR) technology plays an increasingly important role in dealing with large and ever-expanding data sources. SAR techniques are widely used, including: the computational simulation design of virtual chemical libraries to explore molecular diversity for subsequent synthesis and screening; screening proprietary, commercial, and public databases to discover lead ...

Eicosanoid, including prostaglandin (PG), thromboxane (TX), leukotriene (LT), and lipoxin (LX), is critical signaling molecule. Prostanoid, a subset of eicosanoids, comprises PG and TX. Prostanoids are named based on the number of carbon-carbon double bonds in their molecules. Most biologically active PGs and TXs belong to the series 2 molecules with two carbon-carbon double bonds. ...

Endocannabinoids are amphipathilic molecules synthesized from phospholipids in the nervous system. They are a part of the endocannabinoid system, which includes G protein-coupled receptors. The most extensively studied endocannabinoids are N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol ...

Bioactive peptides are short protein fragments of 2-50 amino acids in length that are linked by covalent bonds (called amide bonds or peptide bonds). Bioactive peptides have the advantages of simple structure, high biological activity, high specificity and low toxicity, and have broad prospects in the design and development of new peptide ...

Activity-based protein profiling (ABPP) is a versatile and powerful chemoproteomic technique, utilizing activity-based probes (ABPs) that selectively and covalently interact with the active sites of proteins. This approach allows for the capture and analysis of tagged proteins using various proteomic tools. ABPP facilitates the global and quantitative examination of protein functional states in ...

Saving Money For The Hospital; What is the cost of a peripheral IV restart? A 2018 study of 55 consecutive peripheral IV dislodgements at Deaconess Hospital in Evansville, Indiana showed that the cost is $48. This number takes into account lost medicine, IV supplies, lost nursing time, changing the bed sheets and gown and other expenses. This $48 restart cost can be further broken down into ...

Rivaroxaban is a prescription medicine for treatment of thromboembolic diseases mainly used to treat and prevent the symptoms of the deep vein thrombosis (DVT) prior to hip or knee replacement surgery, treat the venous thromboembolism (VTE) and nonvalvular atrial fibrillation, and treat DVT and pulmonary embolism (PE). Alfa Chemistry offers high quality of rivaroxaban which meets the CP. Please ...

Knock-in mice have an insertion in a specific locus in order to produce genetically modified mice for customised research purposes. Reporter genes, human genes, related genes from the same organism, or point mutations can be introduced into the protein-coding region of a gene to produce knock-in mice. The difference between the knock-in and knockout approach is that knock-in mouse models are ...