Pre-Clinical Equipment & Supplies In Newfoundland

The Environics Series Reduced Oxygen Breathing Device 2 is the next generation system that simulates altitude exposure and can be utilized for both research and hypoxia ...

Bertin Bioreagent offers primary and secondary antibodies for laboratories. As essential tools, they are particularly versatile when properly ...

The Environics Series Reduced Oxygen Breathing Device 3 is the newest in our line of systems that simulate altitude exposure and can be utilized for both research and hypoxia training. It is customizable for expanded research ...

Celastrol (tripterine) is a chemical compound isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities. It has been shown to have ...

Apoptosis Detection Reagent, Annexin V-AF 594 Conjugation ...

Our conditionally-immortalized allogeneic cell lines are derived from hematopoietic stem cells and allows us to eliminate the need for recurring donors. From a single cell line, we can produce unlimited quantities of consistent fully-functional cells with targeted ...

G Protein-Coupled Receptors (GPCRs) are involved in a wide range of physiological and pathological processes and represent a large class of drug targets accounting for >30% of all drugs on the market. These drugs, however, only cover 15% of the entire GPCR family, and many valuable receptors remain undrugged. In particular, GPCRs whose natural ligands are large peptides or small proteins are ...

NextDent Indirect Bonding Tray is a biocompatible Class I material for orthodontic applications. Making use of the right dental software, you can plan the exact location of orthodontic brackets and design the Indirect Bonding Tray. Due to the flexible characteristics of the printed indirect bonding trays, orthodontist can easily place all the brackets at once, saving time at the chair. Available ...

Targeted therapies are revolutionizing oncology. Patients with chronic myeloid leukemia treated with the tyrosine kinase inhibitors (TKI) now have life expectancies approaching that of the general population. Imatinib (Gleevec®, Gilvec®) the first TKI approved has substantial efficacy in chronic myeloid leukemia (CML) and gastrointestinal stromal ...

Puracyp’s nuclear receptor activation kits are all-inclusive cell-based assay systems. The kits incorporate mycoplasm-free, stably-transfected cells derived from hepatoma cell lines that have been treated with a cell-arrest agent to prevent further proliferation. Exposure to the cell-arrest agent ensures that the cells in the kits can only be used for a single 96 well assay. Each kit ...

Oxyntomodulin is a naturally occurring hormone produced in the colon, shown to bind both the GLP-1 and glucagon receptor, regulating both blood glucose appetite and lipid metabolism. OPKO Health is developing OPK88003, a long-acting, once weekly oxyntomodulin analog for the treatment of type 2 diabetes and ...

Hyacyst 120 PFS is as effective as combination GAG layer therapy (iAIuRil®)1 in a convenient syringe. Higher concentration option when increased replenishment of the GAG layer is ...

The CUSTOMFLEX® ARTIFICIALIRIS is intended for use as an iris prosthesis for the treatment of iris defects. The CUSTOMFLEX® ARTIFICIALIRIS is indicated for use in children and adults for the treatment of full or partial aniridia resulting from congenital aniridia, acquired defects, or other conditions associated with full or partial aniridia. When implanted, the CUSTOMFLEX® ...

SkinEthicTM RHEACF is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. Improved production so every single process is guaranteed devoid of any animal constituents and tissue production now guaranteed devoid of any animal components with traceability of all ingredients. ...

Immatics’ TCER molecules can be produced and purified utilizing established processes to manufacture ...

Strong scientific and clinical rationale for LSD1/HDAC6 inhibition in haematological and solid ...

Strong scientific and clinical rationale for novel small molecule PD-L1 ...

Our mRNA platforms and vast in-house experience help partners quickly optimize, screen and select an mRNA code, develop a candidate, and ensure effective & prime manufacturing of the mRNA from research grade to GMP scale. Our platform’s scale and flexibility is uniquely suited to respond to the needs of development partners across a wide range of therapeutic ...

ExThera’s proprietary Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100) is a first and only commercially available pathogen agnostic adsorption therapy, CE Marked for Europe, and given Emergency Use Authorization (EUA) in the United States. Seraph 100 has been validated through several preclinical studies and a clinical study in Europe to reduce both drug-resistant and ...

Calcitonin (salmon) is a 32-amino acid polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). The calcitonin receptor has been cloned and shown to be a member of the ...