EnColl Corporation

Our History 

EnColl was founded in 1994 by Dr. S. Gunasekaran. He is recognized as one of the world's foremost collagen experts. EnColl's proprietary collagen production technology makes the company a leader in this field. The Twice Treatment Process (TTP) and other unique purification steps of the patented technology results in a pure (99%), less immunogenic and better biocompatible collagen than those that are currently in the commercial market (proven pre-clinical studies). Further patented surface modified or energized collagen, 'CollagenPRO', can be used for different biomedical applications. The company currently uses this patented technology to develop additional, advanced biotech products.

ENCOLL'S COLLAGEN TECHNOLOGY

EnColl's technology is based on a Two-step enzyme Treatment Process (TTP) for the modification and purification of Type-I collagen resulting in 99% pure Type-I collagen. EnColl's Type-I collagen is the purest, least immunogenic and highly bioactive, making it the ideal choice for the treatment, therapy and regeneration of tissue system(s) as it applies to various medical applications.

Papain, an enzyme extracted from papaya, is known to break the cleavage sites neighboring the disulfide bonds of cysteine. Papain has also been reported to have a lytic (destructive) effect of elastin and bound antibodies the contaminants that are difficult to remove from purified collagen (Coulson, Biochim. Biophys. Acta 237:378, 1971; and Smith et al., Nature 198:1311-2, 1963 ).

After the purification process, EnColl's collagen is further bioactivated by varied degrees of controlled modification of phosphorylation. Purified collagen can be chemically-modified by covalently binding phosphates to hydroxyl groups of hydroxylated amino acids. This reaction likely involves covalent bonding of phosphate to hydroxyl group of serine, tyrosine and/or threonine, hydroxylysine and hydroxyproline. The reaction is controllable to achieve different degrees of bioactivity for varied applications. Encoll's phosphorylated collagen renders unique abilities in the growth of soft or hard tissue as needed by the physiological system.

Collagen has become an important tool for hastening the healing process of injured tissues. Current collagen products (derived through the extraction or recombinant methods) have the potential problems in terms of the purity, immunogenicity and related-problems rendering the collagen unsuitable for bio-medical and research applications. The traditional manufacturers of medical grade collagen and others have agreed that they have considerable amounts of type-III collagen contamination in their products. This results in a 3% rejection of their collagen when implanted in human. Encoll's high purity collagen has proven to be a superior technology solution for all medical applications.

ENCOLL'S COMPETITIVE ADVANTAGE

The unique post-translational modification (phosphorylation) of Collagen through EnColl's patented manufacturing process gives added advantage by enhanced bioactivity useful for a variety of medical applications.

Other common benefits of EnColl's collagen (over other commercially available collagen) in the market are:

• Biocompatibility
• Least Immunogenicity
• Bioresorbability
• Cell Attractability
• Hemostastic Ability
• Structural Stability
• Target Specificity
• Slow and Sustained Release of Bound Drugs
• Increased solubility & Optical clarity at neutral pH after chemical modification
• Enhanced bonding to active drugs or factors
• Available in powder, tubular, gel, film, surface coating, sponge or in fabric form
• Better bioactive coating on inactive surfaces.