Radiotherapy Articles & Analysis

Genomic instability is observed during tumorigenic progression, in a fraction of the progeny of cells surviving irradiation, and also in unirradiated, bystander cells. It is unclear whether communication between irradiated cells themselves, or bystander cells themselves contributes to the observed effect. Herein, we restricted communication between cells by plating human lymphoblasts at low ...

By Inderscience Publishers

In recent years, gold nanoparticles (GNP) have been proposed as sensitising agents in radiotherapy. Several studies, performed both through Monte Carlo simulation of dosimetric and microdosimetric enhancement in presence of GNPs and through in–vitro experiments, have clearly shown the powerfulness of such a technique in radiotherapy. Aim of the present work is to estimate the dose enhancement ...

By Inderscience Publishers

The research summarized in this whitepaper provides a number of examples of how ALZET® pumps offer a superior pre-clinical drug dosing option for the delivery of a wide array of anti-cancer agents, including small molecules, immunotherapies, radiotherapies, combination treatments, and novel drug entities. This whitepaper also explores how ALZET® pumps have been used to successfully test ...

By Charles River

The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter 188Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, ...

By Inderscience Publishers

Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was ...

By Inderscience Publishers

Purpose The incidence and mortality rates of cervical cancer are declining in the United States; however, worldwide, cervical cancer is still one of the leading causes of death in women, second only to breast cancer. This disparity is at least partially explained by the absence of or comparatively ineffective screening programs in the developing world. Recent advances in expression genomics have ...

By Auspex Diagnostics

Currently, no reliable methods and no suitable marker profile exist that could predict radiosensitivity in patients. This paper describes the irradiation response of lymphocytes, fibroblasts and tumour biopsies cultured in vitro, clonogenic survival at 2 Gy (SF2), chromosomal aberrations, and CD4 and CD8 lymphocyte apoptosis. The results, and other accumulating evidence, strongly suggest that ...

By Inderscience Publishers

Anthropomorphic-anthropometrical phantoms are simulator objects for measuring absorbed dose in conditions equivalent to those found in the exposure of the internal organs to charged particles, photons or neutrons generated by external beams or to internal intake of radioisotopes. This paper addresses the construction of an anatomical simulator that retains the anthropomorphic and anthropometrical ...

By Inderscience Publishers

An adaptive response may be defined as the effect of a small priming dose of radiation modifying the anticipated cellular response of the same tissues so as to alter the predicted response to a larger dose of radiation. We and many others have demonstrated that at low radiation doses (less than 0.5 Gy) the lethal and mutational effect of the radiation is mainly, possibly entirely, due to the ...

By Inderscience Publishers

CURRENT STANDARD OF CARE FOR BRAIN TUMORS The current initial standard of care for aggressive brain tumors—whether they are primary brain tumors (ie, tumors that originate in the brain), or metastatic tumors from cancers that started outside of the brain—is resection. After surgery, a follow-up treatment, also referred to as adjuvant treatment, is often recommended to help eliminate ...

By GT Medical Technologies, Inc.

The Institute of Cancer Research or ICR, is a world leading institution in cancer gene discovery, cancer drugs and innovations in radiotherapy. With the help of Peak's NM30LA gas generator ICR have managed to streamline their workflow. Name: Amin Mirza Job title: Head of Structural Chemistry Company: Institute of Cancer Research Location: London, UK One of ICR’s main priorities is to ...

By PEAK Scientific Instruments Ltd

Radiation therapy choices vary for comprehensive breast cancer treatment. One such option, intraoperative radiation therapy (IORT) is employed in many centers around the country. IORT using the Zeiss® Intrabeam® System has been proven to be non-inferior to External Beam Radiation Therapy (EBRT) in local recurrence and disease-free survival. IORT’s advantage is one treatment during ...

By Videra Surgical Inc.

Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...

By Alfa Cytology

Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the treatment paradigm of some hematological tumors. However, adoptive T cell therapy remains of little success in solid tumors. The main reason is that ...

By Creative BioMart

Breast cancer is the malignant tumor with the highest morbidity and mortality among women worldwide. At present, the main therapeutic methods include surgery, chemotherapy, radiotherapy, endocrine therapy and targeted therapy, etc. The development and marketing of new drugs have far-reaching significance in improving the survival of breast cancer patients and changing the pattern of breast cancer ...

By Biopharma PEG Scientific Inc

Researchers at the Children's Hospital of Philadelphia (CHOP) have made a breakthrough in the treatment of aggressive solid cancers, and they have developed a new cancer treatment that targets proteins within tumor cells that are essential for tumor growth and survival, but this has not been possible before. Using the power of large data and advanced computational methods, researchers can ...

By Creative BioMart

The proton beam was investigated for cancer cell therapy in the pancreas. Neon ion interaction profiles were compared with the result of the proton beam, which was investigated for nanoscale ion beam interactions. Simulation for the Bragg peak calculation was performed for interactions with a human organ, the pancreas. The results show the absorbed dose and dose equivalent, which vary with the ...

By Inderscience Publishers

Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by proteases ...

By Creative Proteomics

At a time when medical imaging technology is rapidly advancing, one of the oldest materials, platinum iridium marker bands, still stands out as the gold standard in medical imaging. While more modern alternatives have been developed over recent years that offer cheaper and lighter solutions, few can match this classic material's reliability and durability. For anyone requiring precise results ...

By Edgetech Industries LLC

CASE PRESENTATION A 70-year-old female recently diagnosed with metastatic pancreatic cancer presented with acute new onset of lower back pain. The patient was taking chemotherapy, participating in a drug therapy trial, and had received radiation therapy. There was no history of acute trauma to the pelvic or acetabular region. Magnetic resonance imaging revealed bilateral fragility fractures, with ...

By CurvaFix, Inc.