Pathology Clinical Articles & Analysis
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Mortuary Management using Matrix tracker case study
The Ashford and St Peter's NHS Trust in the UK has chosen Matrix Tracker to manage and track the transition of bodies through the hospital mortuary. Organisation Ashford and St. Peter's Hospitals NHS Trust was formed in April 1998 and manages two sites; Ashford Hospital in Middlesex and St. Peter's Hospital in Chertsey, Surrey. The mortuary at Ashford and St Peters Hospital (ASPH) is an ...
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RNA Sequencing Increases the Chance of RNA Biomarker Discovery
Biomarkers are defined as measurable biological characteristics that are associated with normal or pathological conditions. They possess clinical relevance, including diagnostic, prognostic, and predictive values. RNA, not only an essential part of the central dogma, is certainly a relatively untapped resource for biomarker discovery of various diseases. Cumulating data shows that RNA ...
By CD Genomics
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Adaptive MRD Chief Commercial Officer Nitin Sood Shares How His Personal Journey Has Shaped His Career Path
Here at Adaptive, putting the patient first is a core value—a philosophy that deeply resonates with me. Similar to many of my fellow Adapters, my inspiration is personal and I’m excited by the tremendous potential impact we can have on human lives through the work we’re doing in our Immune Medicine and MRD businesses. Growing up in New Delhi, India, my father worked for a ...
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High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Highlights Deterministic barcoding in tissue enables NGS-based spatial multi-omics mapping DBiT-seq identified spatial patterning of major tissue types in mouse embryos Revealed retinal pigmented epithelium and microvascular endothelium at cellular level Direct integration with scRNA-seq data allows for rapid cell type identification Summary We present ...
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Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
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A new perspective regarding laser therapy
In April of this year, prior to the beginning of our International Conference in Toronto, I had the rare opportunity to meet for several hours with Tiina Karu, Mary Dyson, Shimon Rochkind, Chukuka Enwemeka and several other leading authorities involved in the field of laser technology. Whereas their interests encompass basic research, pathology, tissue response mechanisms and clinical ...
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LimFlow Percutaneous Deep Venous Arterialization
What interested you in LimFlow, and how did you get involved in the PROMISE I trial? Dr. Clair: Practicing vascular surgery, where a number of patients are evaluated for chronic limb-threatening ischemia (CLTI), you are guaranteed to have patients who are not candidates for percutaneous or surgical revascularization. These patients often have arterial systems open or identifiable to the ankle, ...
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Spatial profiling of chromatin accessibility in mouse and human tissues
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
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