Neurology Disease Articles & Analysis

Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...

By Johnson Controls, Inc.

Today marks a historic day for all the scientists and researchers who have dedicated their lives to advancing our understanding of Alzheimer’s Disease over the last 20 years. For the more than 6 million individuals living with Alzheimer’s disease in the US, their families, and their caretakers, our team at Altoida celebrates the positive topline data reported on the CLARITY AD global ...

By Altoida, Inc.

The COVID-19 pandemic has catalyzed the implementation of decentralized clinical trials in neurology, bringing the immense benefits of clinical trials to light. This industry-wide push towards trial decentralization has emerged as a key element for improving clinical trial efficiency and improving the experience for patients and physicians. By utilizing digital technologies, such as wearables, ...

By Altoida, Inc.

The Atlas 2030, the world's only exoskeleton for children, is capable of achieving much more effective therapy in the treatment of Spinal Muscular Atrophy The Mak Active Knee, the exoskeleton that works like a robotic knee, is achieving previously impossible rehabilitations due to speed and absence of pain Elena Garcia Armada, founder of Marsi-Bionics and scientific researcher at the CSIC, ...

By Marsi Bionics, S.L.

Targeted protein degradation (TPD) is a promising strategy in the field of drug discovery. In recent years, targeted protein degradation (TPD) technology has developed rapidly, especially proteolysis targeting chimera (PROTAC), which is the most representative technology of TPD strategy. TPD drugs are one of the hot spots of new drug development in recent years, especially in the field of ...

By Hunan Huateng Pharmaceutical Co. Ltd.

More and more scientific evidence shows that reactive oxygen species (ROS) and reactive nitrogen species are important mediators of signaling events in cells, especially the superoxide anion in reactive oxygen species. If the content of superoxide anion in the human body is too high, it may induce various diseases, including pro-inflammatory diseases (pro-inflammatory diseases), cardiovascular ...

By Creative Enzymes

Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a multifactorial disorder with an interplay of biological, psychological, and external factors, and ...

By Creative Biolabs

1 billion people around the world are currently suffering from neurological disorders, and the number is growing by the day. The COVID-19 pandemic has had a significant negative impact on the healthcare system’s ability to effectively diagnose and treat these individuals. However, despite the growing numbers, action has not been taken by world leaders, creating a huge unmet need. This ...

By BrainQ Technologies

To understand the significance of the SpinTech MRI STAGE software platform, it helps to begin by asking a question: Given that MRI is an incredibly powerful diagnostic tool for neurological diseases like Alzheimer’s, dementia, Parkinson’s and multiple sclerosis (MS), why have radiologists and neurologists had to choose between conducting faster MRI exams and obtaining higher-quality ...

By SpinTech, Inc.

Understanding the complex world of drug discovery and development necessitates familiarity with key players in cellular communication. A pivotal group in this arena is G Protein-Coupled Receptors (GPCRs). These receptors play a crucial role in transmitting signals across cell membranes, significantly influencing numerous physiological processes. Consequently, GPCRs have become a central focus in ...

By Creative Bioarray

Peptidomimetics are structural analogs of peptides or proteins that mimic their biological activities. They are designed to overcome limitations associated with peptides, such as poor stability and bioavailability by preserving or enhancing their functions. Peptidomimetic development involves the design and synthesis of molecules that mimic three-dimensional structures and functional groups of ...

By Alfa Cytology

Recently, the Wolf Foundation published a list of Wolf Chemistry Award winners in 2022, with honors from Professor Bonnie L. Bassler at Princeton University, Professor Carolyn R. Bertozzi at Stanford University, and Professor Benjamin F. Cravatt III at the Scripps Institute. The press release points out that these scientists have made pioneering contributions to understanding the chemistry behind ...

By Profacgen

Collaboration Announced Between Researchers at University of California Irvine and Population Diagnostics, Inc. at Rare Disease Event in Southern California The Spooner Girls Foundation , University of California, Irvine School of Medicine, (UCI) and Population Diagnostics, Inc. (PDx), announced today a collaborative research initiative focused on the NUBPL gene at the Spooner family’s ...

By Population Bio, Inc. a Precision Medicine Company

Protein kinases are effective anti-cancer drug targets that have been proven in many experiments and facts. Many small molecule protein kinase inhibitors approved by the FDA can be used for cancer treatment. The effectiveness of kinases as targets for other diseases, including neurological disorders, inflammation and metabolic diseases, is also being tested. Human protein kinase consists of more ...

By BOC Sciences

The phrase “not all heroes wear capes” springs to mind when speaking with BrainQ’s Chief Scientific Officer (CSO) and Co-founder, Prof. Esther Shohami. A world-renowned expert and pioneer in neurotrauma research, Esty utilizes her vast experience to direct the development and implementation of the company’s scientific and research operations. But that’s just the ...

By BrainQ Technologies

Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene ...

By CD Genomics

In the vast and intricate world of biology, the development of proteins and antibodies stands as a crucial field of study, driving advancements in medicine, biotechnology, and beyond. From the fundamental building blocks of life to the complex molecules that defend our bodies, these remarkable biomolecules hold the key to unlocking new frontiers in scientific understanding and practical ...

By CD ComputaBio

Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradation of target proteins, with folate serving as a key ligand. In this study, the ...

By BOC Sciences

Introduction Ion channels are integral membrane proteins that facilitate the passage of ions across cell membranes. This process is vital for numerous physiological functions, including muscle contraction, neurotransmission, and maintaining cellular homeostasis. The modulation of ion channels has emerged as a significant target in drug discovery, particularly for conditions such as cardiac ...

By Creative Biogene

Introducing Beacon Biosignals: a neurotechnology company founded to develop machine learning-enabled EEG neurobiomarkers and accelerate precision medicine for any disease state affecting the brain Founded by MD/PhDs and engineers from Harvard and MIT, Beacon is propelled by the vision of a computing platform designed to scale the interrogation of large brain datasets with unprecedented ...

By Beacon Biosignals, Inc.