Neurodegenerative Disease Articles & Analysis

Introduction Magnetic resonance imaging offers a wide variety of contrast mechanisms to study soft tissue in the body. Using the complex data from the SWI scans, it is possible to produce magnetic source images using a novel reconstruction method that takes the phase data and reconstructs what is referred to as a quantitative susceptibility map (QSM). The phase images represent local frequency ...

By SpinTech, Inc.

Raphaël ROYER, founder and director at Centre Brain-Moove, shares his experience with us : “ Having used transcutaneous vibration for a long time, I naturally turned towards the almost daily use of Vibramoov in the context of brain injury patients. The use of Vibramoov gives hope and different management possibilities for patients with neurodegenerative diseases (Multiple ...

By Techno Concept

Persistent histone phosphorylation refers to the continuous or long-term phosphorylation of specific amino acid residues (usually serine or threonine) on histones under certain cellular conditions or stimuli. This phosphorylation is usually catalyzed by specific kinases (such as protein kinase A, protein kinase C, or MAP kinase) and can be reversed by phosphatases. Persistent histone ...

By MtoZ Biolabs

Modern society is exposed daily to electromagnetic fields (EMFs) generated by home/environmental human activity. The question of the possible risk to health by long-term exposure to weak fields became a concern in that even small health effects could have profound public health implications. The knowledge of the biological effects of electromagnetic fields still contains certain gaps which should ...

By Inderscience Publishers

Histone SUMOylation is a post-translational modification that involves the covalent linking of the SUMO protein to the lysine residues of histones. This process requires the participation of a series of enzymes, including E1 activating enzyme, E2 conjugating enzyme and E3 ligase. SUMOylation plays a key role in gene expression regulation, DNA repair, RNA processing and nuclear transport in the ...

By MtoZ Biolabs

Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...

By Altoida, Inc.

Phosphoprotein sequencing is a technique used to analyze protein phosphorylation modifications. Phosphorylation is an important post-translational protein modification that affects the function, activity, stability, and interactions of proteins by adding phosphate groups to specific amino acid residues (usually serine, threonine, or tyrosine) on proteins. The purpose of phosphoprotein sequencing ...

By MtoZ Biolabs

Differentially expressed proteins refer to proteins that show significant changes in their expression levels in different biological samples or under different treatment conditions. Observing such differential expression is crucial for understanding cellular physiology and disease mechanisms. For example, some proteins may be upregulated or downregulated in health and disease states, or between ...

By MtoZ Biolabs

Ubiquitination detection of proteins is a biochemical technique used to identify and analyze ubiquitination modifications on proteins. Ubiquitination is a post-translational modification process that involves the covalent linkage of the small protein ubiquitin to lysine residues of a target protein, a modification that plays a crucial role in the regulation of protein degradation, signal ...

By MtoZ Biolabs

Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of post-translational modification of ...

By MtoZ Biolabs

These proteins belonging to the HAT family are essential for life because they transport amino acids to the cell membrane. Although members of the family are nearly identical, they selectively transport certain amino acids. This specificity determines their involvement in specific functions, such as cell growth or neuronal function, and consequently in related diseases, such as cancer or ...

By Creative Biostructure

Abnormal accumulation of misfolded tau in filaments is characteristic of many neurodegenerative diseases—precisely for this reason, these neurodegenerative diseases are collectively referred to as tauopathy. The Michel Goedert team and the Sjors Scheres team at the Molecular Biology Laboratory of the Medical Research Council in Cambridge, UK, witnessed the use of cryo-EM to dissect tau ...

By Creative Biostructure

The ubiquitination site of a protein refers to those specific amino acid residues on the protein molecule that can covalently bind with Ubiquitin. Ubiquitin is a small protein that plays an important regulatory role in cells, particularly in protein degradation and signal transduction. Ubiquitination is a post-translational modification process where ubiquitin molecules are attached to specific ...

By MtoZ Biolabs

Oxidative phosphorylation is the process by which mitochondria produce ATP (adenosine triphosphate) in the cellular respiration chain. It is a crucial step in cellular energy metabolism. In this process, electrons are transferred from one carrier to another through a series of oxidation-reduction reactions and are ultimately passed to oxygen to form water. The energy released by this electron ...

By MtoZ Biolabs

In biomedical research, the detection and analysis of biomarkers are crucial. Among them, glycoproteins are an essential biomarker that plays a key role in many biological processes, including disease onset, progression, and treatment response. The Tandem Affinity Purification (TAP) of glycoprotein is an efficient detection method.What Is a Glycoprotein?Firstly, let's understand what a ...

By MtoZ Biolabs

In post-translational modification (PTM) of proteins, ubiquitination is considered one of the most critical processes in regulating cellular functions and various diseases. The identification of ubiquitination sites becomes very crucial for understanding the mechanisms of ubiquitination-related biological processes. Experimental and computational methods can be used to identify ubiquitination ...

By MtoZ Biolabs

Autophagy is an intracellular system that degrades cytosolic proteins and organelles. Autophagy can be divided into three groups: macroautophagy, microautophagy and chaperon-mediated autophagy (CMA). Macroautophagy is most extensively studied and best known among the three pathways. When macroautophagy is induced, an isolation membrane encloses a portion of cytoplasm, forming a characteristic ...

By Creative Biogene

Acetylation detection of a specific protein is a method used to determine whether and where acetylation modifications have occurred on a protein. Acetylation is a common post-translational modification of proteins, typically occurring on lysine residues of proteins, and plays a crucial role in regulating protein function, cell signaling, gene expression, and disease onset. For instance, the ...

By MtoZ Biolabs

In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...

By CD ComputaBio

Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...

By Creative BioMart