Gut Microbiome Articles & Analysis

What we eat and how it is processed by the gut is proving to be more important that ever. Research is showing that the gut microbiome has a significant impact on the brain. Brain health in impacted in significant ways both negatively and positively based upon the gut microbiome. Structural bacterial components can stimulate the brain to improve the immune system. When the gut microbiome is ...

By Pluton Biosciences, Inc.

Food allergies are on the rise to level not seen in previous generations. Many hypotheses have been put forward as to the cause of increases in these food allergies. New studies involving mice have shown that certain probiotics being introduced into the gut Microbiome of these mice have been able to stop certain food allergies, such as an allergy to peanuts. By introducing the probiotic the ...

By Pluton Biosciences, Inc.

Durham, NC (April 28, 2020) - A review article published in PNAS highlights Symberix's efforts to understand the role of the human microbiota in drug efficacy and toxicity. Symberix co-founder Matt Redinbo is featured in the article alongside other leaders from the emerging field of “pharmacomicrobiomics” -- the study of mechanisms behind the microbial impact on drug metabolism. ...

By Symberix, Inc.

MedBiome’s founders reported in Microbiome the development of the RapidAIM platform to screen compounds against individual microbiomes in vitro. They tested 43 compounds (including 4 antibiotics) against 5 individual microbiomes using the RapidAIM technology. The RapidAIM workflow provides insights into microbiome absolute abundance and functional responses to ...

By MedBiome Inc.

The gut is a complex ecosystem that contains an extremely large community of microbes known as the gut microbiome. The gut microbiome is made up of bacteria, archaea, viruses, fungi, and other eukaryotic microorganisms, including yeasts, flagellates, ciliates, and protozoa. The gut microbiota of a healthy individual consists of six phyla (Firmicutes, Bacteroidetes, Proteobacteria, ...

By Creative Proteomics

Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versatile physiological functions and ...

By Creative Enzymes

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...

By KoBioLabs

Symbiotic microbial groups within the digestive tract of herbivores are the main source of depolymerized lignocellulases. The dolphin is the largest extant rodent, usually living in the Pantanal wetland and Amazon basin, and is also known as the "king of grass" due to its diet based on grasses and aquatic plants. They can efficiently depolymerize and utilize lignocellulosic biomass through ...

By CD BioGlyco.

With rapid development in sequencing technology, researchers can better assess the effect of the gut microbiome on human health. Human beings have a symbiotic relationship with the microbiota since birth. The environment, proximity to other humans and animals, diet, genetics, and time changes can all affect the microbial composition of our skin, mouth, and intestines. Compared with other ...

By Creative Proteomics

The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...

By CD Genomics

The link between the vaginal microbiome and pregnancy outcomes is so strong that someone’s vaginal microbiome can actually be used to predict IVF success What is the vaginal microbiome? Your vaginal microbiome is the community of microbes living in your vagina. A healthy vaginal microbiome typically has low diversity and is dominated by a type of good bacteria called Lactobacillus that ...

By Juno Bio

Disease-causing microbes are often found in the human microbiome. So, when does the presence of pathogenic microbes indicate an infection? And when does the presence of infection explain disease? What is an infection? What is a disease? A disease associated with microbes is the outcome of interaction(s) between a microbe(s) and its host in which the host suffers some sort of damage. ...

By Galaxy Diagnostics, Inc.

Bile acids are synthesized in the liver from cholesterol as a raw material. As a natural "emulsifier", they can promote the dissolution, digestion and absorption of fats, fat-soluble vitamins, etc. Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to ...

By Creative Proteomics

Organs influenced by immune dynamics in the gut.(1) A Gut Check for Tumor Overgrowth Enzymes Work Better in a Cage Are IPS Cells Safe for Therapeutic Use? Factors contributing to autoimmune disease development. (2) The human body is the site of a flagrant yet silent invasion. We host as many foreign organisms in and on us as we have cells that make up our own body. A particular ...

By Pluton Biosciences, Inc.

The variety of normal and diseased human tissues needed to perform comprehensive screening of drug candidates is a key resource for next-generation preclinical models, but obtaining these tissues is challenging. Gene editing enables Altis Biosystems to offer a diverse array of RepliGut® human gut models tailored for specific research programs. Many Challenges Around Accessing Tissues ...

By Altis Biosystems

The microbiome has been shown to play roles in many different disease processes and is implicated in many more, from infectious and gastrointestinal diseases to autoimmune and neurological disorders. Advanced models of the gut leveraging intestinal and colonic stem cells are enabling the development of more reliable and robust systems for evaluating the impact of changes in the microbiome on gut ...

By Altis Biosystems

Advanced microphysiological systems can replicate aspects of intestinal complexity, such as epithelium self-renewal by stem cells in in vitro crypts or the interactions of microbes and intestinal epithelium mediated by a mucus layer. Availability of such models is key to progress in compound screening, disease modeling, and microbiome research. Defining a Niche A niche is a multidimensional ...

By Altis Biosystems

Hydrogen and methane breath testing (HMBT) is a non-invasive diagnostic tool frequently used to assess small intestinal bacterial overgrowth (SIBO) and carbohydrate malabsorption disorders such as lactose and fructose intolerance. Despite its widespread use in adults, its application in children is less standardised, and clinicians often face uncertainties about adapting adult protocols for the ...

By Bedfont Scientific Limited

The rise in recent decades of diseases such as inflammatory bowel disease and rheumatoid arthritis suggests that factors in the environment are contributing. In 1932, New York gastroenterologist Burrill Crohn described an unusual disease in 14 adults. The patients had bouts of abdominal pain, bloody diarrhea, and lesions and scars on the bowel wall. Doctors in other parts of North America and ...

By Ensia