Clinical Testing Articles & Analysis

The release of antimicrobial substances into surface waters is of growing concern due to direct toxic effects on all trophic levels and the promotion of antibiotic resistance through sub-inhibitory concentration levels. This study showcases (1) the variation of antibiotics in sanitary sewage depending on different timescales and (2) a method to assess the antibiotic resistance based on an ...

By IWA Publishing

Nuritas has discovered two ingredients called PeptiYouth and PeptiStrong that can be integrated into everyday products, including serums and supplements, to fight the effects of aging on skin and muscles. The company names stem cell aging as a growing focus for start-ups. It also says one of consumers’ most significant concerns is combating the adverse effects of aging. Nuritas uses its ...

By Nuritas Ltd.

Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. Using the K562-mb15-41BBL cell line as a stimulus, we obtained large numbers of activated NK cells from the peripheral blood of healthy donors. ...

By Nkarta, Inc.

When promising drug candidates are identified for further investigation in clinical trials, sponsor companies are usually optimistic about outcomes. But there are times, when after years of sunk effort and resources, clinical trials fail to bring a viable drug to market. Frequently, a drug fails for safety or efficacy reasons that are beyond a sponsor’s control. However, to some degree, ...

By Seascape Clinical

One major challenge for implementing stem cell treatment in the clinics, is the interdisciplinary work required by stem cell biologists and medical doctors as well as the state-of-the-art equipment needed at public hospitals to successfully translate the basic stem cell knowledge into clinical products. Our facility directly serves to speed up the development cell therapeutics, by establishing an ...

By Baker

Derek Lacarrubba was allergic to New York City. Lacarrubba, 31, got stuffed up around cats, dogs, three kinds of dust mites and several varieties of native New Yorkers - trees, that is. He couldn't sleep. He had trouble going to the gym. And as an attorney, he was too busy to commit to the years-long treatments doctors typically recommend: weekly shots at the doctor's office or holding liquid ...

By Allovate Therapeutics

Abstract Objective: Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, stored on site at hospitals, and be immediately available for arterial vascular reconstruction. Although the HAV is acellular when implanted, ...

By Humacyte, Inc.

Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...

By Creative Bioarray

Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...

By Creative Bioarray

Founded in 2014 in California, AXIM® Biotechnologies, Inc. is a vertically integrated research and development company focused on improving the landscape for diagnosis of ophthalmological conditions such as Dry Eye Disease (DED) through rapid diagnostic tests. Additionally, it owns IP and has conducted research on SARS-CoV-2 (COVID-19) rapid neutralizing antibody tests to detect ...

By IUL S.A.

According to the Centre for Disease Control and Prevention, CDC report 2017; 30.3 million Americans – 9.4 percent of the U.S. population had diabetes in 2015. Home blood glucose monitoring is useful to determine the daily adjustments in treatment or insulin intake. It is advised to follow doctor's recommendations about how often to test the glucose levels. According to an article published ...

By Epinex Diagnostics Inc

The BEAR Implant is the first medical advancement to enable your body to heal its own torn anterior cruciate ligament (ACL). That’s a big deal, because until now your ACL would have been replaced with either another tendon from your body or a tendon from a deceased donor. The BEAR Implant is different because it works with your own blood to heal the torn ends of your ACL back ...

By Miach Orthopaedics, Inc.

Balance is achieved and maintained by a complex set of sensorimotor control systems. (check What is Balance?) When any of these systems is injured or deficient, balance can markedly be affected. Therefore, it is important to have tools that can help health professionals identify if there is a balance problem and the specific nature and/or the cause of the problem. Several conditions like stroke, ...

By Sensing Future Technologies

Antibody drugs, particularly monoclonal antibodies (mAb), play a critical role in the treatment of many diseases, especially in the treatment of cancer and immunological disorders. To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.Definition of Antibody ActivityThe activity of an antibody drug usually refers to its ability to bind to the ...

By MtoZ Biolabs

Peroxidase, usually derived from horseradish, is a common enzyme used in clinical testing reagents. It is widely used not only in several biochemical assays but also in immunoassay (ELISA) kits. As a key component of the color development system of several kits, peroxidase has an important impact on the quality of the kits. Horseradish peroxidase (HRP) is the most commonly used enzyme because ...

By Creative Enzymes

What is cystic fibrosis? Cystic fibrosis (CF) is a rare genetic disorder that affects the lungs, digestive system, and other organs. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a protein that regulates chloride ions transport across cell membranes. These mutations cause the CFTR protein to be either absent or not function ...

By Protheragen

Preclinical drug discovery represents a critical phase in the development of new therapeutics. It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. Central to this phase is the use of appropriate disease models, which are essential for understanding the ...

By Creative Biogene

Today, HIT remains a critical clinical context in many hospital settings, when heparin, mainly unfractionated, is used in cardiology, intensive care units, or ECC, including CPB and increasingly ECMO. This is a paradoxal disease, as this anticoagulant drug can provoke thrombocytopenia associated with thrombosis in affected patients. Detecting the risk of HIT is mandatory, as it requires an ...

By Emosis Diagnostics SAS

Background: The CAREGIVER Thermometer Model PRO-TF300 (Thermomedics Inc., Delray Beach, FL) is a non-contact clinical professional thermometer used to read human body temperature in children and adults through the determination of infrared energy from the middle of the forehead. The purpose of this paper is to describe the methods and findings of the CAREGIVER’S validation for clinical use ...

By Thermomedics, Inc.

Background. The CAREGIVER® Model PRO-TF200 and PRO-TF300 (Thermomedics, Miami, FL) are non-contact clinical professional thermometers used to read human body temperature in children and adults through the determination of infrared energy from the middle of the forehead. Both models function identically, thus they will be referred to hereafter as "CAREGIVER". The purpose of this paper is to ...

By Thermomedics, Inc.