Electrospinning Technology of Recombinant Human Collagen

Electrospinning can produce continuous fibers on the micro - and nano-scale. The high flexibility and low cost of the material make electrospinning very attractive. In addition, the high specific surface area, porosity, and similarity to ECM ensure that the electrostatic pad promotes cell adhesion, skin regeneration, nutrient and oxygen transport, moisture retention, exudate removal, and hemostasis. Therefore, electrospinning nanofibers are particularly suitable for wound dressings and other applications in tissue engineering.

With the rapid development of science and technology, the raw materials used in electrospinning tend to be diversified, such as natural polymers and synthetic polymers. Recombinant human collagen, a natural biosynthetic material with good biocompatibility, low immunogenicity, degradability and absorbability, has been widely used in hemostasis, wound healing, drug slow-release carrier and tissue process. And it can be processed by electrospinning technology.

Based on EDC/NHS crosslinked recombinant Human collagen Type III (rhCol III), Dong [1] et al. prepared a nanofiber membrane wound dressing containing multiple Gly-Glu-Lys and Gly-Leu-Ser-Gly-Glu-Arg integrin receptors by electrospinning. This wound dressing effectively promoted cell adhesion, proliferation and migration in vitro. In a full-layer wound model of mice, it could accelerate wound healing, greatly improve collagen deposition, and restore dermal and epidermal structures and skin appendages.

* EDC—1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride,
* NHS—N-hydroxysuccinimide

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